What do current treatments for Asthma do?
The primary treatments for asthma are inhaled steroids that reduce the overall inflammation, and long-acting beta-2-adrenergic receptor agonists that reduce acute bronchoconstriction events. While steroids do treat the inflammation that underlies the disease, they are not well tolerated as a long-term treatment. Beta-agonists, do not treat the underlying disease, only the acute symptoms, and patients can become less responsive to even the acute relief benefits with long-term treatment. For patients who are not well-controlled with steroid treatment, injection of IgE-titrating antibodies have been effective but they do not treat neutrophilic asthma such as is characteristic of some environmental pathogens.Therefore, there is an unmet need for alternative treatments for asthma.